074 ALK-positive desmoplastic Spitz naevus in a patient with corresponding ALK-positive anaplastic large cell lymphoma
نویسندگان
چکیده
Aim:Spitz naevus is a benign melanocytic tumour with distinct histopathological features of spindle-shaped melanocytes. An understanding genetic aberrations can help to characterise the different subsets Spitzoid neoplasms. Anaplastic lymphoma kinase (ALK) tyrosine receptor that was first described in pathogenesis anaplastic large cell (ALCL). ALK mutations have been reported up 10% Spitz tumours.This study describes rare occurrence an mutation two diseases same patient – ALCL and naevus. Method:Presentation, management, clinical outcomes were retrospectively reviewed for ALK-positive at tertiary paediatric hospital. Result:The 14-year-old female 12-month history red-brown plaque on right shoulder.This background stage III treated chemotherapy stem transplantation. She underwent surgical excision skin lesion. Histopathological examination showed desmoplastic A bone marrow aspirate trephine (BMAT) axillary lymph node time diagnosis also revealed mutation. currently remission 2 years post Conclusion:Our case reports coincidence having disease processes. There has one similarly literature cutaneous naevi fusion partner gene (TPM3). Whilst this not fully understood, further studies may identify whether independent lineages, or fragile site similarity which predispose translocation event.
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2022
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2022.05.009